Here are my preferred keystrokes. Note, keystrokes separated by a comma mean you have to use them in sequence in order to activate the command.
They refer to VS2012 but some may also work in previous versions.
Launch Application without debugging (usually faster than with debugging enabled)
Stop a debugging session
Comment the selected part
Un-comment the selected part
Place the cursor in the Quick-Launch box for then executing some menu command
Open the "Navigate to" dialog...probably the most powerful command for mouse-less navigation
Navigate backwards in the cursor position history
Navigate forwards in the cursor position history
Collapse to definitions
This is the default combination for closing windows on nearly all win apps I know, but strangely not on Visual Studio. Therefore, the first thing I do is to remap it to `File.Close`.
Go To Test/Code
Quickly jumping to the according test class. Just right-click and select the corresponding menu item.